Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria |
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| Affiliation: | 1. Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA;2. Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand;1. Phytochemistry, Analytical Chemistry Laboratory, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;2. Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;3. Department of Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;1. Department of Medical Zoology, Mie University School of Medicine, Mie, Tsu 514-8507, Japan;2. Department of Molecular Protozoology, Research Center for Infectious Disease Control, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan;1. Malaria Biochemistry Laboratory, The Francis Crick Institute, London, UK;2. Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;3. Division of Molecular Parasitology, Proteo-Science Center, Ehime University, Ehime, Japan;1. Division of Molecular Parasitology, Proteo-Science Centre, Ehime University, Matsuyama, Japan;2. Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;3. Pathogen Genomics Group, Bioscience Programme, Biological and Environmental Science and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Kingdom of Saudi Arabia;4. CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA-HB), IDMIT Department, IBFJ, DRF, Fontenay-aux-Roses, France |
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| Abstract: | Malaria is a life-threatening disease caused by infection with Plasmodium parasites. The goal of developing an effective malaria vaccine is yet to be reached despite decades of massive research efforts. CD4+ helper T cells, CD8+ cytotoxic T cells, and γδ T cells are associated with immune responses to both liver-stage and blood-stage Plasmodium infection. The immune responses of T cell-lineages to Plasmodium infection are associated with both protection and immunopathology. Studies with mouse model of malaria contribute to our understanding of host immune response. In this paper, we focus primarily on mouse malaria model with blood-stage Plasmodium berghei infection and review our knowledge of T cell immune responses against Plasmodium infection. Moreover, we also discuss findings of experimental human studies. Uncovering the precise mechanisms of T cell-mediated immunity to Plasmodium infection can be accomplished through further investigations using mouse models of malaria with rodent Plasmodium parasites. Those findings would be invaluable to advance the efforts for development of an effective malaria vaccine. |
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