Synthesis and cytotoxic activities of 4,5-diarylisoxazoles |
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| Authors: | Sun Chang-Ming Lin Lee-Gin Yu Hsi-Jung Cheng Chih-Yu Tsai Ya-Chuan Chu Chi-Wei Din Yi-Hui Chau Yat-Pang Don Ming-Jaw |
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| Affiliation: | National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC. |
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| Abstract: | A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively. |
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