| Abstract: | The antinociceptive properties of dalargin (D) under nembutal anesthesia and artificial ventilation were studied in hemodynamic response to mechanical algesic stimulation in rats. D was introduced i/v (20 micrograms/kg) against a background of myoplegia with Arduan (0.1 mg/kg) and without it. The naloxon (100 micrograms/kg) prevented the protective effects of D. It is considered that injection of D (20 micrograms/kg) on the background of total myoplegia and artificial ventilation prevented hemodynamic response on algesic stimulus. Subsequent dose increase of opium peptide up to 3500 micrograms/kg does not cause amplification of protective properties. |
