Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics |
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| Authors: | Sum Phaik-Eng How David Torres Nancy Newman Howard Petersen Peter J Mansour Tarek S |
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| Affiliation: | Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA. sump@wyeth.com |
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| Abstract: | A series of benzoxazole derivatives of the mannopeptimycin glycopeptide antibiotics was synthesized via a novel benzoxazole formation reaction by treating aminophenol of mannopeptimycin-beta with an aldehyde and DDQ in DMF. Some of these derivatives (e.g., 5b, 5d, 5m, and 7b) showed good activity against Gram-(+) bacteria when compared to the parent compound mannopeptimycin-beta. |
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