Effect of cholinomimetics on the release and uptake ofl-[3H] glutamic acid in rat neostriatum |
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| Authors: | O V Godukhin A Yu Budantsev O V Selifanova V N Agapova |
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| Institution: | 1. Laboratory of Synapse Structure and Function, Institute of Biological Physics, USSR Academy of Sciences, 142292, Pushchino, Moscow Region, USSR
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| Abstract: | The effects of cholinomimetics on the release and uptake of L-glutamic acid have been studied by means of local superfusion of rat neostriatum (in vivo) and using striatum slices (in vitro). Cholinomimetics regulate the release of L-glutamic acid through both muscarinic (m-) and nicotinic (n-) choline receptors according to the mechanism of negative feedback. Cholinomimetics regulate release through presynaptic receptors. The effect of n-cholinomimetics is mediated by neostriatum interneurons. |
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