Vanadate counteracts glucagon effects in isolated rat hepatocytes |
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| Authors: | M Miralpeix J Gil J L Rosa J Carreras R Bartrons |
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| Institution: | Departament de Ciències Fisiològiques Humanes i de la Nutrició, Universitat de Barcelona, Zona Universitària, Spain. |
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| Abstract: | The incubation of isolated rat hepatocytes with vanadate increased the concentration of fructose 2,6-bisphosphate without modifying 6-phosphofructo-2-kinase activity. Vanadate also reverted and prevented the decrease of fructose 2,6-bisphosphate levels, of the "active" form of the 6-phosphofructo 2-kinase and of the pyruvate kinase activity ratio produced by glucagon, by probably counteracting the increase in cyclic AMP concentration. |
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