Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells |
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| Institution: | 1. Physics Institute, Universidad Autónoma de San Luis Potosí, Ave. Dr. M. Nava #6, San Luis Potosí, SLP 78290, Mexico;2. Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322, United States;1. The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;2. Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;3. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;1. Pole d’endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université Catholique de Louvain, B-1200 Brussels, Belgium;2. Section of Cell Biology, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, London W13 0NN, United Kingdom;3. CNRS UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France;4. INSERM U661, Institut de Génomique Fonctionnelle, Montpellier, France;5. Institut de Génomique Fonctionnelle, Universités de Montpellier 1 et 2, Montpellier, France |
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| Abstract: | Mitochondria play a central role in glucose metabolism and the stimulation of insulin secretion from pancreatic β-cells. In this review, we discuss firstly the regulation and roles of mitochondrial Ca2+ transport in glucose-regulated insulin secretion, and the molecular machinery involved. Next, we discuss the evidence that mitochondrial dysfunction in β-cells is associated with type 2 diabetes, from a genetic, functional and structural point of view, and then the possibility that these changes may in part be mediated by dysregulation of cytosolic Ca2+. Finally, we review the importance of preserved mitochondrial structure and dynamics for mitochondrial gene expression and their possible relevance to the pathogenesis of type 2 diabetes. |
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| Keywords: | Type 2 diabetes Mitochondria β-cells Insulin secretion |
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