Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis |
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| Institution: | 1. Lomonosov Moscow State University, Faculty of Fundamental Medicine, Department of Biochemistry and Molecular Medicine, Lomonosovsky Prospekt 31-5, Moscow, 117192, Russia;2. IFOM – the FIRC Institute of Molecular Oncology, Via Adamello 16, Milan, 20139, Italy;1. Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 300070 Tianjin, China;2. Tianjin Institute of Animal Husbandry and Veterinary Medicine, Tianjin Xiqing District Jin Jing Highway 17 Kilometers, 300381 Tianjin, China;3. Department of Cell Biology and Research Centre of Basic Medical Science, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 300070 Tianjin, China |
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| Abstract: | We highlight a recent paper which documents the important role that Ca2+ release through type-1 Inositol 1,4,5-trisphosphate receptor (IP3R1) plays in the acute regulation by glucagon of gluconeogenesis in hepatocytes. The specificity is likely the result of discrete localization close to mitochondria and PKA-dependent phosphorylation of IP3R1 which enhances Ca2+ release. |
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| Keywords: | Inositol 1 4 5-trisphosphate receptors Hepatocytes Glucagon signaling PKA-phosphorylation Gluconeogenesis |
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