Calcium & ROS: Two orchestra directors for the requiem of death |
| |
| Affiliation: | 1. Center for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile;2. Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, Chile;3. Escuela de Tecnología Médica, Facultad de Ciencias, Universidad Mayor, Santiago, Chile;4. Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile;1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy;2. Section of Cardiology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;3. Division of Cardiology, “Sacro Cuore” Hospital, Negrar (VR), Italy;4. Division of General Medicine and Diabetes Unit “Sacro Cuore” Hospital, Negrar (VR), Italy;1. Gazi University, Faculty of Medicine, Department of Medical Pathology, Ankara, Turkey;2. Gazi University, Faculty of Medicine, Department of Public Health, Ankara, Turkey;1. Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois |
| |
| Abstract: | Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion. |
| |
| Keywords: | TNF Calcium ROS Ryanodine receptor Regulated necrosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
