Calcium signaling and epigenetics: A key point to understand carcinogenesis |
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| Institution: | 1. Departamento De Bioquímica, Facultad De Medicina. Universidad Nacional Autónoma De México, Ciudad De México, Mexico;2. Instituto De Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico;1. Cellular Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain;2. Pathology Service, Hospital San Pedro de Alcantara, 10003 Cáceres, Spain;1. KU Leuven, Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, Campus Gasthuisberg O/N-I bus 802, Herestraat 49, 3000 Leuven, Belgium;2. KU Leuven, Laboratory of Molecular & Cellular Signaling, Department of Cellular & Molecular Medicine, Campus Gasthuisberg O/N-I bus 802, Herestraat 49, 3000 Leuven, Belgium |
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| Abstract: | Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since epigenetic mechanisms are disrupted in all stages of carcinogenesis, and reversibly regulate gene expression, they have been studied by different research groups to understand their role in Ca2+ signaling remodeling in cancer cells and the carcinogenic process. In this review, we link Ca2+ signaling, cancer, and epigenetics fields to generate a comprehensive landscape of this complex group of diseases. |
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| Keywords: | Calcium signaling Cancer Epigenetics Gene expression |
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