Potassium-dependent sodium-calcium exchanger (NCKX) isoforms and neuronal function |
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| Institution: | 1. Laboratory of Sensory Signaling, Bogomoletz Institute of Physiology, Kyiv, Ukraine;2. Department of Cytology, Bogomoletz Institute of Physiology, Kyiv, Ukraine;3. Laboratory of Molecular Biophysics, Bogomoletz Institute of Physiology, Kyiv, Ukraine;4. International Center for Molecular Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukraine;1. KU Leuven, Department of Cardiovascular Sciences, Laboratory of Experimental Cardiology, 3000 Leuven, Belgium;2. K.G. Jebsen Center for Cardiac Research, University of Oslo, Oslo, Norway;1. Department of Anaesthesia, Intensive Care Medicine, Pain Therapy, Justus-Liebig-University Giessen, Rudolf-Buchheim-Str. 7, D-35392 Giessen, Germany;2. Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK;1. Brain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, ON, Canada;2. Department of Physiology, University of Maryland, Baltimore, MD, USA |
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| Abstract: | K+-dependent Na+/Ca2+-exchangers (NCKX) are a relatively recently described five-member gene family of transporters which play a quantitatively significant role in neuronal Ca2+ transport. In this review we highlight the important individual contributions these transporters make to cellular Ca2+ homeostasis and neuronal function. Notably, different members of the family make distinct, non-redundant, contributions to critical behavioural pathways. In particular, NCKX proteins regulate the kinetics, termination and adaptation of Ca2+ signals in sensory transduction neurons in the olfactory and visual systems. Similar contributions to shaping the spatial and temporal features of Ca2+ signals in neurons at other key brain locations have important consequences for the circuitry influencing control of satiety, for experience-dependent motor learning and spatial working memory retention, as well as in the protection of neurons in the face of toxic stimuli. NCKX proteins are also key contributors to a variety of events in other tissues. The connection between NCKX isoform function and human phenotype and disease is an emerging area, and we anticipate that future research will reveal rich new details in the coming years. |
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| Keywords: | K-dependent Na/Ca-exchangers Neuronal function |
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