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A STIMulating journey into optogenetic engineering |
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| Affiliation: | 1. Dept. of Internal Medicine/Cardiology, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA;2. Dept. of Physiology & Biophysics, Rush University Medical Center, 1750 W. Harrison St, Chicago, IL 60612, USA |
| Abstract: | Genetically-encoded calcium actuators (GECAs) stemmed from STIM1 have enabled optical activation of endogenous ORAI1 channels in both excitable and non-excitable tissues. These GECAs offer new non-invasive means to probe the structure-function relations of calcium channels and wirelessly control the behavior of awake mice. |
| Keywords: | Calcium signaling CRAC channel Optogenetics STIM1 |
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