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No social distancing between ORAI channels |
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| Affiliation: | 1. Fels Institute for Cancer Research and Molecular Biology Philadelphia, PA, 19140, USA;2. Department of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine, Philadelphia, PA, 19140, USA;1. Institute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, Linz, 4020 Austria |
| Abstract: | ORAI1 is established as an essential component of Ca2+ release-activated Ca2+ (CRAC) channel which mediates store-operated Ca2+ entry (SOCE). However, the contributions of ORAI2 and ORAI3 to SOCE are not understood. We highlight a recent study which shows that ORAI proteins form heteromeric channels which tune SOCE over a range of stimulus intensities. |
| Keywords: | Native ORAI channels NFAT activation Stimulus intensities Agonist |
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