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Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites |
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| Authors: | Jinyou Zhang Arnold L. Demain |
| Affiliation: | (1) Fermentation Microbiology Laboratory, Department of Biology, Massachusetts Institute of Technology, 02139 Cambridge, MA, USA |
| Abstract: | The activity of  -l- -aminoadipyl)-l-cysteinyl-d-valine catalysis. Addition of l-cysteine to fermentation media increased  -lactam production in both organisms and alleviated the negative carbon source regulation by glycerol in S. clavuligerus. |
| Keywords: | Regulation ACV synthetase activity Glucose Glyceraldehyde-3-phosphate ATP l-cysteine |
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