用电导法研究悬浮介质中大分子物质对红血球细胞(RBC)聚集的一种抑制效应

通常认为悬浮介质中的大分子物质促进RBC聚集的桥联作用,使RBC聚集,但在高浓度时,大分子物质反而抑制RBC聚集。过去认为主要是高浓度大分子物质影响了RBC表面势能,但我们在研究中发现,在一定条件下低浓度的大分子物质也能抑制红细胞聚集。这说明:大分子物质对RBC聚集的抑制效应,不仅能通过改变RBC膜表面势能实观,还能通过其它途径实现,这种途径之一就是影响RBC膜的力学性质。

AN INHIBITION EFFECT OF MACROMOLECULES ON RBC AGGREGATION STUDIED WITH CONDUCTIVE METHOD

The macromolecules in suspending medium were usually looked upon as an agent bridging two erythrocytes and enhancing RBC aggregation. But, macromolecules in high concentration can inhibit RBC aggregation. The reason was considered to be that macromolecules in high concentration can enhance RBC surface potential. But, we found macromolecules in low concentration can also inhibit RBC aggregation under certain condition. The results show that the macromlecules not only can affect RBC surface potential, but also can destroy mechanical property of RBC membrane. This is another inhibition effect of macromolecules on RBC aggregation.