Reappraisal of the regulation of lactococcal L-lactate dehydrogenase |
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Authors: | van Niel Ed W J Palmfeldt Johan Martin Rani Paese Marco Hahn-Hägerdal Bärbel |
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Institution: | Department of Applied Microbiology, Lund University, Lund SE-221 00, Sweden. ed.van_niel@tmb.lth.se |
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Abstract: | Lactococcal lactate dehydrogenases (LDHs) are coregulated at the substrate level by at least two mechanisms: the fructose-1,6-biphosphate/phosphate ratio and the NADH/NAD ratio. Among the Lactococcus lactis species, there are strains that are predominantly regulated by the first mechanism (e.g., strain 65.1) or by the second mechanism (e.g., strain NCDO 2118). A more complete model of the kinetics of the regulation of lactococcal LDH is discussed. |
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