Natural killer cell-target interactions: the role of 4F2 antigen in the human system |
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| Authors: | A I Chin T S Yen |
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| Affiliation: | 1. Department of Protein Science, Div. Protein Engineering, AlbaNova University Center, KTH Royal Institute of Technology, S-114 21 Stockholm, Sweden;2. Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, N-0424 Oslo, Norway;3. Precision Immunotherapy Alliance, Institute of Clinical Medicine, University of Oslo, N-0313 Oslo, Norway;4. Oncopeptides AB, S-171 48 Stockholm, Sweden;5. Science For Life Laboratory, S-171 65 Solna, Sweden;1. Innate Pharma, Marseille, France;2. Assistance Publique des Hôpitaux de Marseille, Chirurgie Urologique et Transplantation Rénale, Hôpital de la Conception, Marseille, France;3. Assistance Publique des Hôpitaux de Marseille, ORL et Chirurgie Cervico-Faciale, Hôpital de la Conception, Marseille, France;4. Assistance Publique des Hôpitaux de Marseille, Service d''Oncologie Médicale et de Soins Palliatifs, CHU Timone Adulte, Marseille, France;5. Assistance Publique des Hôpitaux de Marseille, Oncologie Médicale, Hôpital de la Timone, Marseille, France;6. Université Paris-Saclay, INSERM, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France;7. Aix Marseille University, CNRS, INSERM, CIML, Marseille, France;8. Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Marseille-Immunopôle, Marseille, France;1. Biomedical Pioneering Innovation Center (BIOPIC), Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University, Beijing 100871, China;2. Changping Laboratory, Beijing 102206, China;3. Department of Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;4. Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen 518132, China;5. Ninth School of Clinical Medicine, Peking University, Beijing 100038, China;6. The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China |
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| Abstract: | The manner by which natural killer cells discriminate between target and nontarget cells is a subject of intense investigation. Recently, the antigen recognized by the 4F2 monoclonal antibody has been implicated as the target recognition molecule of cloned human natural killer cells. Here we report the results of our studies on the possible role of 4F2 antigen in target recognition by natural killer cells present in the peripheral blood. In our hands, the 4F2 antibody only weakly blocked the killing of K562 leukemia cells by human natural killer cells. Furthermore, no correlation was observed between the level of cell surface 4F2 antigen and the natural killer susceptibility of several tumor cell lines, the ability of these cells to bind to natural killer cells, or the ability of these cell lines to compete with K562 cells in a natural killer assay. Therefore, the 4F2 antigen does not appear to be the target recognition molecule of most peripheral blood natural killer cells. |
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