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Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis |
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| Authors: | Pathak Ashish K Pathak Vibha Riordan James M Gurcha Sudagar S Besra Gurdyal S Reynolds Robert C |
| Affiliation: | Drug Discovery Division, Southern Research Institute, PO Box 55305, Birmingham, AL 35225-5305, USA. |
| Abstract: | Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. Herein, we describe the synthesis of alpha-(1-->2)- and alpha-(1-->6)-linked mannopyranosyl disaccharides possessing a 5-azidonaphthlene-1-sulfonamidoethyl group as photoaffinity probes for active-site labeling studies of mannosyltransferases in Mycobacterium tuberculosis. |
| Keywords: | Mannose Disaccharide Photoaffinity probe Mannosyltransferases Mycobacterium tuberculosis |
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