1H, 13C and 15N assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis |
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| Authors: | A Neumoin A Leonchiks P Petit L Vuillard M Pizza M Soriani R Boelens A M J J Bonvin |
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| Institution: | (1) Bijvoet Center for Biomolecular Research, Science Faculty, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands;(2) ASLA Biotech, Riga, Latvia;(3) BioXtal, Marseille, France;(4) Novartis, Siena, Italy; |
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| Abstract: | GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography,
understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants
of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete 1H, 13C and 15N resonance assignments of GNA1946 (residues 10–287) in aqueous buffer solution. |
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