Mammalian metallothionein in toxicology,cancer, and cancer chemotherapy |
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| Authors: | Mohammad Namdarghanbari William Wobig Susan Krezoski Niloofar M. Tabatabai David H. Petering |
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| Affiliation: | (1) Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, USA;(2) Department of Medicine, Medical College of Wisconsin, Waukesha, USA;; |
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| Abstract: | The present paper centers on mammalian metallothionein 1 and 2 in relationship to cell and tissue injury beginning with its reaction with Cd2+ and then considering its role in the toxicology and chemotherapy of both metals and non-metal electrophiles and oxidants. Intertwined is a consideration of MTs role in tumor cell Zn2+ metabolism. The paper updates and expands on our recent review by Petering et al. (Met Ions Life Sci 5:353–398, 2009). |
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