Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists |
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| Authors: | Oon Han Hee Kim Seung Hae Kim Kyoung-Hee Hur Gwong-Cheung Joo Yim Hyeon Chung Hee-Kyung Ho Woo Sung Dong Koo Ki Lee Chang-Seok Sung Koh Jong Kim Geun Tae |
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| Institution: | Research and Development, LG Life Sciences, 104-1 Munji-dong, Yuseong-gu, Daejon 305-380, Republic of Korea. |
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| Abstract: | Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model. |
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