Secretion of extracellular proteins by Pseudomonas aeruginosa |
| |
Authors: | A Lazdunski J Guzzo A Filloux M Bally M Murgier |
| |
Affiliation: | Laboratoire de Chimie Bactérienne du CNRS, Marseilles, France. |
| |
Abstract: | Pseudomonas aeruginosa is a bacterial species of commercial value secreting numerous extracellular proteins, involved in pathogenesis. Most strains produce at least a lipase, a phospholipase, an alkaline phosphatase, an exotoxin and 2 proteases (elastase and alkaline protease). Various mechanisms for secretion of exoproteins appear to exist in P aeruginosa. Genetic analysis has led to the identification of 2 secretion pathways: i) a "general" secretion pathway, defined by the xcp mutations, which mediates secretion of most extracellular proteins, and; ii) an independent secretion pathway specific for alkaline protease. Our present knowledge on the pathways and components of the secretion machinery in P aeruginosa is reviewed in this article. |
| |
Keywords: | |
|
|