Sea urchin eggs in the acid reign |
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| Authors: | Morgan Anthony J |
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| Affiliation: | Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, United Kingdom |
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| Abstract: | Sea urchin eggs have been an indispensable model system for studying egg activation and ionic signalling for at least a century. Instrumental in the discovery of two Ca2+-mobilizing second messengers, cyclic ADP-ribose and NAADP, the sea urchin has revolutionized cell biology for all phyla. This review attempts to summarize what we currently know about egg acidic vesicles in the context of Ca2+ signalling. The dynamics of Ca2+ storage, Ca2+ mobilization, proton fluxes and two-pore channels will be discussed. |
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| Keywords: | NAADP cADPR IP3 Ca2+ Sea urchin egg Yolk platelets Acidic Ca2+ stores Endosomes Lysosomes Cortical granules pH Two-pore channel TPC Fertilization |
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