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Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex |
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| Authors: | Nosá?ová G Capek P Fle?ková D Jure?ek L Hindák F Lukavský J Cepák V Ray B Breierová E Turjan J |
| Institution: | a Department of Pharmacology, Jessenius faculty of Medicine, Comenius University, Sklabinská 26, SK-036 01 Martin, Slovakia b Institute of Chemistry, Center of Glycomics, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38 Bratislava, Slovakia c Institute of Botany, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 23 Bratislava, Slovakia d Academy of Sciences of the Czech Republic, Institute of Botany, Department of Plant Ecology, Centre for Bioindication and Revitalisation, Dukelská 135, CZ-379 82 T?eboň, Czech Republic e Natural Products Laboratory, Department of Chemistry, The University of Burdwan, WB 713 104 India |
| Abstract: | An algal extracellular biopolymer (over 8.5 × 105 Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11-12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3-4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view. |
| Keywords: | Red alga Rhodella grisea Proteoglycan Cough Antitussive activity Smooth muscle |
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