Synthesis and characterization of pH-dependent glycol chitosan and dextran sulfate nanoparticles for effective brain cancer treatment |
| |
| Authors: | Saboktakin Mohammad Reza Tabatabaie Roya M Maharramov Abel Ramazanov Mohammad Ali |
| |
| Institution: | a Nanostructured Materials Synthesis Laboratory, International Research Institute of Arian Chemie Gostar, Tabriz, Iran
b Nanotechnology Research Center, Baku State University, Baku, Azerbaijan |
| |
| Abstract: | A novel drug delivery system for the treatment of brain tumors was formulated by methotrexate (MTX)-loaded polymeric nanoparticles (NPs) based on Glycol chitosan (GCS) and Dextran sulfate (DS). The physicochemical properties of resulting particles were investigated, evidencing the contribution of these nanoparticles for brain targeting. In vitro release of MTX was also evaluated. The GCS-DS nanoparticles have been developed based on the modulation of ratio show promise as a system for controlled delivery of the drug to the brain. |
| |
| Keywords: | Glycol chitosan Dextran sulfate Drug delivery Brain tumors Nanoparticles |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
