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Structural features and bioactivities of the chitosan |
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| Authors: | Chen Gang Mi Jie Wu Xiaohou Luo ChunLi Li JiaBing Tang YaXiong Li Jie |
| Institution: | a Department of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China b Department of Emergency, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China c Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China |
| Abstract: | Fourier transform infrared (FT-IR) spectroscopic studies (3500-600 cm−1) showed some different bands of chitosan. The absorption at 3439 cm−1 is stretching vibration of -OH and -NH2 bonds, indicating the association of the hydrogen-bond between them. The bands at 1659, 1599 and 1321 cm−1 are attributable to the peaks of stretching vibrations of amide I (ν(C O)), II (δ(N-H)), and the peak of stretching and bending vibrations of III (ν(C-N)) (δ(N-H)). The chitosan showed strong free radical scavenging activities. Pretreatment with chitosan significantly prevented the decrease of antioxidant enzymes activities and the increase of p-JNK at 3 h after renal ischemia and reduced renal tubular epithelial cell apoptosis. |
| Keywords: | Chitosan FT-IR p-JNK NO |
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