Free and Conjugated Amines in Human Lumbar Cerebrospinal Fluid |
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| Authors: | Gertrude M Tyce Duane K Rorie David E Byer David R Danielson |
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| Institution: | Departments of Physiology, Mayo Clinic, Rochester, Minnesota, U.S.A.;Departments of Anesthesiology, Mayo Clinic, Rochester, Minnesota, U.S.A. |
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| Abstract: | Significant amounts of acid-hydrolyzable conjugates of 3,4-dihydroxyphenylethylamine, norepinephrine, and 5-hydroxytryptamine were detected in lumbar CSF from 22 awake unpremedicated healthy individuals. In the CSF samples, the amounts of conjugated amines almost always exceeded the amounts of free amines, but were less than the amounts of the acid metabolites 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindoleacetic acid. |
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| Keywords: | Dopamine Norepinephrine Serotonin Cerebrospinal fluid |
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