Evaluation of Epicardial Fat Tissue Thickness in Patients with Primary Hyperparathyroidism |
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| Affiliation: | 1. Department of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;2. Department of Cardiology, Bergama Government Hospital, Izmir, Turkey;3. Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;4. Department of Endocrinology and Metabolism, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey;5. Department of General Surgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;6. Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;7. Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara University, Ankara, Turkey.;1. Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China;2. Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China;1. Department of Internal Medicine;2. Division of Endocrinology, Saint Vincent Hospital, Worcester, Massachusetts 01608.;1. Divisions of Endocrinology and General Surgery Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School;2. General Surgery, Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School,;3. Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.;1. Department of Clinical and Experimental Medicine, Section of Endocrinology, Research Center of Excellence AmbiSEN;2. Department of Clinical and Experimental Medicine, Section of Gynecology, University of Pisa, Pisa, Italy. |
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| Abstract: | ObjectivePrimary hyperparathyroidism (pHPT) affects the cardiovascular system, and epicardial fat tissue (EFT) thickness is closely associated with cardiovascular diseases and atherosclerosis. Despite this, the association between EFT thickness and pHPT has not been studied in a clinical setting. This study aimed to assess EFT thickness in patients with pHPT.MethodsThe study included 38 patients with pHPT and 40 healthy controls. EFT thickness, carotid intima-media thickness (CIMT), serum levels of parathormone (PTH) and calcium, and blood chemistry profiles were determined in all subjects. Correlation and regression analyses were performed with EFT thickness and CIMT as dependent variables and age; systolic and diastolic blood pressure; body mass index (BMI); presence of diabetes mellitus; and free plasma glucose (FPG), PTH, and serum calcium (Ca) levels as independent variables.ResultsBoth the mean EFT thickness and the mean CIMT were significantly greater in the pHPT group than the control group (P < .001 for both). Correlation analysis showed that EFT thickness was significantly correlated with CIMT, age, systolic blood pressure, and PTH and serum Ca levels. Furthermore, the regression analysis revealed that EFT thickness retained its independent and positive association with FPG and serum Ca levels.ConclusionsThe results of this study indicate that EFT thickness may be a useful marker of early atherosclerosis in patients with pHPT. Furthermore, the increase in EFT thickness appears to be due to hypercalcemia. (Endocr Pract. 2014;20:26-32) |
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