Association Between Thyroid Function and Objective and Subjective Sleep Quality in Older Men: The Osteoporotic Fractures in Men (MrOS) Study |
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| Institution: | 1. Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, California;2. Department of Epidemiology and Biostatistics, University of California, San Francisco, California;3. Stanford Preventive Research Center, Stanford University School of Medicine, Stanford, California;4. Veterans Affairs Medical Center, Minneapolis, Minnesota;5. Research Institute, California Pacific Medical Center, San Francisco, California;6. Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, California;7. Department of Pulmonary, Critical Care and Sleep Medicine Case Western Reserve University School of Medicine, Cleveland, Ohio;8. Department of Psychiatry, University of California at San Diego, La Jolla, California;9. Department of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.;1. Departments of Medicine;2. Departments of Cellular and Integrative Physiology;3. Departments of Biochemistry;4. Departments of Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.;1. Department of Cardiology, Seogwipo Medical Center, Jeju, Republic of Korea;2. Department of Cardiology, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea |
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| Abstract: | ObjectiveTo determine the association between thyroid hormone levels and sleep quality in community-dwelling men.MethodsAmong 5,994 men aged ≥ 65 years in the Osteoporotic Fractures in Men (MrOS) study, 682 had baseline thyroid function data, normal free thyroxine (FT4) (0.70 ≤ FT4 ≤ 1.85 ng/dL), actigraphy measurements, and were not using thyroid-related medications. Three categories of thyroid function were defined: subclinical hyperthyroid (thyroid-stimulating hormone TSH] < 0.55 mIU/L), euthyroid (TSH, 0.55 to 4.78 mIU/L), and subclinical hypothyroid (TSH > 4.78 mIU/L). Objective (total hours of nighttime sleep TST], sleep efficiency SE], wake after sleep onset WASO], sleep latency SL], number of long wake episodes LWEP]) and subjective (TST, Pittsburgh Sleep Quality Index score, Epworth Sleepiness Scale score) sleep quality parameters were measured. The association between TSH and sleep quality was examined using linear regression (continuous sleep outcomes) and log-binomial regression (categorical sleep outcomes).ResultsAmong the 682 men examined, 15 had subclinical hyperthyroidism and 38 had subclinical hypothyroidism. There was no difference in sleep quality between subclinical hypothyroid and euthyroid men. Compared to euthyroid men, subclinical hyperthyroid men had lower mean actigraphy TST (adjusted mean difference 95% confidence interval (CI)], − 27.4 − 63.7 to 8.9] minutes), lower mean SE (− 4.5% − 10.3% to 1.3%]), and higher mean WASO (13.5 − 8.0 to 35.0] minutes]), whereas 41% had increased risk of actigraphy-measured TST < 6 hours (relative risk RR], 1.41; 95% CI, 0.83 to 2.39), and 83% had increased risk of SL ≥ 60 minutes (RR, 1.83; 95% CI, 0.65 to 5.14) (all P > .05).ConclusionNeither subclinical hypothyroidism nor hyperthyroidism is significantly associated with decreased sleep quality. (Endocr Pract. 2014;20:576-586) |
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