Vitamin D,Parathyroid Hormone,and Serum Lipid Profiles in a Middle-Aged and Elderly Chinese Population |
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| Institution: | 1. Department of Cardiology;2. Department of South-building Cardiology, PLA General Hospital, Beijing.;1. Department of Pediatric Endocrinology and Diabetes, University of Iowa Hospital and Clinics;2. Health and Human Physiology, University of Iowa;3. College of Public Health, University of Iowa, Iowa City, Iowa.;1. Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, California;2. Department of Epidemiology and Biostatistics, University of California, San Francisco, California;3. Stanford Preventive Research Center, Stanford University School of Medicine, Stanford, California;4. Veterans Affairs Medical Center, Minneapolis, Minnesota;5. Research Institute, California Pacific Medical Center, San Francisco, California;6. Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, California;7. Department of Pulmonary, Critical Care and Sleep Medicine Case Western Reserve University School of Medicine, Cleveland, Ohio;8. Department of Psychiatry, University of California at San Diego, La Jolla, California;9. Department of Medicine, Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.;1. Emergency Department, Sant’Andrea Hospital, School of Medicine and Psychology “Sapienza” Univesity, Rome, Italy;2. Emergency Medicine Department, Parma Teaching Hospital, Parma, Italy;3. Emergency Medicine Department, San Matteo Teaching Hospital, Pavia, Italy;4. Emergency Medicine Department, S. Orsola–Malpighi Teaching Hospital, Bologna, Italy;5. Emergency Medicine Department, Maggiore Teaching Hospital, Milan, Italy;6. Emergency Medicine Department, Città della Scienza e della Salute Hospital, Turin, Italy;7. Emergency Medicine Department, Vittorio Emanuele Teaching Hospital, Catania, Italy;8. Internal Medicine Department, SS Giovanni e Paolo Hospital in Venice, University of Padua, Italy;9. Emergency Medicine Department, San Martino Teaching Hospital, Cenoa University, Italy;10. Clinical and Molecular Medicine Department Sant’Andrea Hospital, School of Medicine and Psychology “Sapienza” Univesity, Rome, Italy;1. Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece;2. First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece;3. Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.;1. Baylor College of Medicine, St. Luke’s Medical Center, The Pituitary Center, Houston, Texas;;2. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada |
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| Abstract: | ObjectivesTo explore the associations of serum vitamin D and parathyroid hormone (PTH) levels with serum lipid profiles and the risk of hyperlipidemia in a middle-aged and elderly population.MethodsA population-based cross-sectional study was conducted in the spring of 2012 among 1,203 Chinese participants, aged 52 to 101 years. 25-Hydroxyvitamin D 25(OH)D] was measured by chemiluminescence assay. (PTH) levels were measured with an electrochemilumines-cence immunoassay (ECLIA) method.ResultsA total of 1,203 participants, including 526 women (43.7%), were evaluated in 2012. The median concentrations of serum 25(OH)D and PTH for the entire group were 17.3 ng/mL and 38.3 pg/mL, respectively. Serum 25(OH)D and PTH levels were not independently associated with serum total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol levels in a multivariate adjusted linear regression analysis of 1,027 participants not receiving antihyperlipidemic treatment (P > .05). In logistic regression analyses, serum 25(OH)D and PTH lev-els were not associated with a risk of hyperlipidemia after adjustment for age, sex, heavy drinking, smoking, diabetes, obesity, family history of hyperlipidemia, body mass index (BMI), physical activity, glomerular filtration rate (GFR), fasting glucose, high-sensitivity Creactive protein (hsCRP), calcium, and hemoglobin.ConclusionsSerum 25(OH)D and PTH levels are not independently associated with serum lipid levels or an increased risk of hyperlipidemia in a middle-aged and elderly Chinese population. (Endocr Pract. 2014;20: 556-565) |
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