Serum Monocyte Chemokine Protein-1 Levels Before and After Parathyroidectomy in Patients with Primary Hyperparathyroidism |
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| Affiliation: | 1. Divisions of Endocrinology and General Surgery Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School;2. General Surgery, Departments of Medicine and Surgery, Rutgers Robert Wood Johnson Medical School,;3. Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey.;1. Departments of Endocrinology, Instituto Português de Oncologia de Lisboa;2. Departments of Nuclear Medicine Department, Instituto Português de Oncologia de Lisboa;3. Departments of University Clinic of Endocrinology, Faculdade de Ciências Médicas, Universidade Nova de Lisboa.;1. Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Italy;2. Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy;3. Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;4. Department of Psychiatry, VU University Medical Center/GGZ inGeest, Amsterdam, the Netherlands;5. National Institute on Aging, National Institutes of Health, Baltimore, Maryland.;1. Department of Neurosurgery, Unit-I, Vellore, India;2. Department of Endocrinology, Diabetes, and Metabolism, Christian Medical College and Hospital, Vellore, India;1. department of Endocrinology, Diabetes, and Metabolism; Cleveland Clinic Foundation, Cleveland, Ohio;2. Department of Otolaryngology; Cleveland Clinic Foundation, Cleveland, Ohio;3. Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery and the Neurological Institute; |
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| Abstract: | ObjectiveTo investigate the effects of parathyroidectomy on serum monocyte chemokine protein-1 (MCP- 1) levels in patients with primary hyperparathyroidism (PHPT).MethodsForty-three PHPT patients, age 56 ± 12 years, underwent minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 20 minutes after parathyroid adenoma removal. Serum samples were stored at -70°C until time of assay.ResultsIn 40 PHPT patients with a single adenoma, MCP-1 levels decreased from 342 ± 103 to 250 ± 77 pg/ mL (P < .001) 15 to 20 minutes after parathyroid adenoma removal. MCP-1 levels were positively correlated with intact parathyroid hormone (PTH) levels (R = 0.47; P < .01). In 3 PHPT patients with double parathyroid adenoma, MCP-1 levels did not decrease after removal of the first adenoma but decreased 15 to 20 minutes after second adenoma removal.ConclusionOur results provide evidence that the decrease in serum intact PTH due to minimally invasive parathyroidectomy results in an immediate decrease in serum MCP-1 levels. (Endocr Pract. 2014;20:1165-1169) |
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