Aerobic Fitness and Glycemic Variability in Adolescents with Type 1 Diabetes |
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| Institution: | 1. Department of Pediatric Endocrinology and Diabetes, University of Iowa Hospital and Clinics;2. Health and Human Physiology, University of Iowa;3. College of Public Health, University of Iowa, Iowa City, Iowa.;1. Departments of Medicine;2. Departments of Cellular and Integrative Physiology;3. Departments of Biochemistry;4. Departments of Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.;1. Deparment of Surgery, Montefiore Medical Center, Bronx, New York;2. Medicine-Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York;3. Department of Endocrinology, Montefiore Medical Center, Bronx, New York;4. Department of Surgery, University of Michigan, Ann Arbor, Michigan.;1. Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine;2. Department of Medicine, Northwestern University Feinberg School of Medicine;3. Division of Cardiac Surgery, Northwestern University Feinberg School of Medicine Chicago, Illinois.;1. Department of Cardiology;2. Department of South-building Cardiology, PLA General Hospital, Beijing. |
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| Abstract: | ObjectiveThis study examines the association of fitness on glycemic variability (GV) in adolescents with type 1 diabetes mellitus (T1DM). GV has been associated with high frequency of hyper-and hypoglycemia.MethodsNineteen adolescents with T1DM, ages 14 to 19 years, underwent aerobic fitness testing to determine their maximal aerobic capacity (VO2 max). A continuous glucose monitoring (CGM) device was placed on each subject and worn for 3 to 5 days until a return visit when the subjects underwent a 1-hour treadmill exercise session. Mean amplitude of glycemic excursion (MAGE) was calculated from the CGM data collected between the 2 study visits. Metabolic equivalent (MET), a measure of accumulated metabolic workload during the exercise session, was also calculated.ResultsMean VO2 max was 46.6 ± 6.8 mL/kg/min, with a range of 34.8 to 57.0 mL/kg/min. Mean MET during the exercise session was 577.2 ± 102.4 and ranged from 354.3 to 716.2 METs. There was an inverse association between VO2 max and MAGE (r = ? 0.46; 95% confidence interval CI], ? 0.01 to ? 0.76; P = .048). MET load and MAGE also had an inverse relationship (r = ? 0.48; 95% CI, ? 0.03 to ? 0.77; P = .037).ConclusionGV is inversely associated with fitness and MET load. Aerobic fitness should be promoted in adolescents with T1DM not only because of its multiple beneficial effects but also due to a possible association with GV, leading to fewer extremes in hypo-and hyperglycemia. (Endocr Pract. 2014;20:566-570) |
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