Engineered T cells for cancer treatment |
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Affiliation: | 1. Novo Nordisk, Maaloev, Denmark |
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Abstract: | Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate fibrotic tissue and kill antigen-expressing tumor cells. Various groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence or migratory capacity and increase safety. This review focuses on recent developments in T cell engineering, discusses the clinical application of these engineered cell products and outlines future prospects for this therapeutic modality. |
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Keywords: | cancer treatment CAR T cells genetic modification of T cells immunotherapy |
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