Is Alanine Aminotransferase Associated with Osteopenia in Middle-Aged and Elderly Chinese? |
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| Institution: | 1. Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou China;2. Department of Endocrinology, Ningde Municipal Hospital, Fujian Medical University, Ningde, China;3. Department of Osteology, Wuyishan Municipal Hospital, Fujian Provincial Hospital, Wuyishan, China;4. Department of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.;1. 1st Department of Internal Medicine, University Hospital and Faculty of Medicine Comenius University, Bratislava, Slovakia;2. Department of Medicine (Endocrinology), Columbia University, New York, New York;1. Department of Laboratory Medicine;2. Department of Pediatric Medicine;3. Department of Medicine, National University Hospital, Singapore;1. Division of Endocrinology, Georgetown University, Washington DC;2. Section of Endocrinology, Medstar Washington Hospital Center;3. Medstar Health Research Institute, Hyattsville, Maryland;4. Department of Oncology, National Institutes of Health, Bethesda, Maryland;5. Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland;1. Thyroid, Head and Neck Cancer Foundation, New York, New York;2. Yale University School of Medicine, Section of Otolaryngology, New Haven, Connecticut;3. Mount Sinai Hospital, Nuclear Medicine Associates, New York, New York;4. Albert Einstein College of Medicine, Mount Sinai Beth Israel, Department of Otolaryngology00ADHead and Neck Surgery, Thyroid, Head and Neck Cancer Foundation, New York, New York.;1. Faculty of Medicine, University of Sydney, Sydney, Australia;;2. Garvan Institute of Medical Research, Sydney, Australia;3. Nepean Hospital,Kingswood, Sydney, Australia;;4. School of Medicine, University of Western Sydney, Sydney, Australia;5. ANZAC Research Institute, Sydney, Australia. |
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| Abstract: | ObjectivesTo investigate the association between alanine aminotransferase (ALT) levels and risk of osteopenia in middle-aged and elderly Chinese with ALT within the normal range.MethodsThis was a cross-sectional study. A total of 4,890 men and women (pre- and postmenopausal) aged 40 years or older were randomly recruited from Fujian, China. Each participant was required to complete a questionnaire and then undergo anthropometric, biochemical, and bone mineral density measurements.ResultsThe odds ratio of osteopenia decreased significantly with increasing ALT level at baseline. The three groups (men, pre- and postmenopausal women) were divided by ALT quartiles. In multiple logistic regression models using the first quartile as the reference, after adjusting for corresponding confounding factors, the odds ratios of osteopenia across the other ALT quartiles were 0.576 (95% confidence interval CI], 0.390 to 0.851), 0.654 (95% CI, 0.460 to 0.930), and 0.629 (95% CI, 0.427 to 0.926) for premenopausal women, and 0.949 (95% CI, 0.699 to 1.289), 0.733 (95% CI, 0.540 to 0.995), and 0.692 (95% CI, 0.508 to 0.943) for postmenopausal women (not significant for quartile 2). However, no significantly different results were found in men. Multiple linear regression models showed that serum ALT concentrations were positively associated with the homeostasis model assessment of insulin resistance.ConclusionOur study of middle-aged and elderly Chinese men and women demonstrates that the prevalence of osteopenia is inversely associated with ALT level when ALT is within the normal range. (Endocr Pract. 2014;20: 775-784) |
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