Lysosomal calcium regulates autophagy |
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| Authors: | Diego L Medina Andrea Ballabio |
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| Affiliation: | 1.Telethon Institute of Genetics and Medicine (TIGEM); Pozzuoli, Naples, Italy;2.Medical Genetics; Department of Translational Medicine; Federico II University; Naples, Italy;3.Department of Molecular and Human Genetics; Baylor College of Medicine; Houston, TX USA;4.Jan and Dan Duncan Neurological Research Institute; Texas Children''s Hospital; Houston, TX USA |
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| Abstract: | Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master autophagy regulator TFEB via the phosphatase calcineurin. |
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| Keywords: | autophagy calcineurin lysosomal calcium TFEB TRPML1 |
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