Mobilization and engraftment of peripheral blood stem cells in healthy related donors >55 years old |
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| Affiliation: | 1. Clinical Hematology Department, ICO-Hospital Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, Universitat Autònoma de Barcelona, Badalona, Spain;2. Banc de Sang i Teixits, Hospital Germans Trias i Pujol, Badalona, Spain;3. Clinical Hematology Department, ICO-Hospital Josep Trueta, Girona, Spain;1. Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan;2. Kaneka Corporation, Osaka, Japan;1. Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taiwan;2. Department of Medical Research and Development Linkou Branch, Chang Gung Medical Foundation, Taoyuan, Gueishan, Taiwan;3. Former Microsurgery Fellow, Chang Gung Memorial Hospital; Regional Oncological Institute, University of Medicine and Pharmacy. “Grigore T. Popa,” Iasi, România;4. Division of Plastic and Reconstructive Surgery, Tzu Chi General Hospital at Taipei, New Taipei, Taiwan;5. Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Gueishan, Taiwan;6. School of Medicine, Chang Gung University, Gueishan, Taiwan;7. Graduate Institute of Biomedical Sciences, Chang Gung University, Gueishan, Taiwan;8. Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan;9. Graduate Institute of Cancer Biology and Drug Discovery and Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan;10. R&D Division, Vectorite Biomedica Inc, Taipei, Taiwan;1. Division of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan;1. McGill University, Faculty of Dentistry, Craniofacial Tissue Engineering, and Stem Cells Laboratory, Montreal, Quebec, Canada;2. Harvard Medical School, Faculty of Medicine, Boston, Massachusetts, USA;3. Nagasaki University Graduate School of Biomedical Science, Department of Regenerative Oral Surgery, Nagasaki, Japan;4. McGill University, Faculty of Medicine, Montreal, Quebec, Canada;5. Fukuoka University, Faculty of Medicine, Fukuoka, Japan;6. University of Toronto, Molecular Genetics Department, Toronto, Ontario, Canada |
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| Abstract: | Background aimsThe increasing scarcity of young related donors has led to the use of older donors for related allogeneic hematopoietic stem cell transplantation (HSCT). This study analyzed the influence of age on the results of mobilization of peripheral blood stem cells (PBSCs) in healthy donors as well as on the engraftment and outcome of HSCT.MethodsA retrospective analysis from a single center was performed comparing the results of PBSC mobilization from related healthy donors according to their age.ResultsThe study included 133 consecutive related donors. The median age was 50 years (range, 4–77 years); 70 (53%) donors were males, and 44 (33%) were >55 years old. All donors were mobilized with granulocyte colony-stimulating factor for 5 days. The peak CD34+ cell count in peripheral blood was higher in younger than in older donors (median, 90.5 CD34+ cells/μL [range, 18–240 CD34+ cells/μL] versus 72 CD34+ cells/μL [range, 20–172.5 CD34+ cells/μL], P = 0.008). The volume processed was lower in younger than in older donors (16,131 mL [range, 4424–36,906 mL] versus 18,653 mL [range, 10,003–26,261 mL], P = 0.002) with similar CD34+ cells collected (579.3 × 106 cells [range, 135.14 × 106–1557.24 × 106 cells] versus 513.69 × 106 cells [range, 149.81 × 106–1290 × 106 cells], P = 0.844). There were no differences in time to recovery of neutrophils and platelets or in the incidences of acute and chronic graft-versus-host disease, overall survival, non-relapse mortality and relapse incidence.ConclusionsDonors >55 years old mobilized fewer CD34+ cells and required a greater volume to collect a similar number of CD34+ cells. The outcome of HSCT was not influenced by donor age. Donor age should not be a limitation for related allogeneic HSCT. |
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| Keywords: | mobilization old related donors stem cell transplantation |
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