A Protracted and Affressive Variant of Lymphocytic Hypophysitis with Mammillary Body Involvement and Cognitive Dysfunction |
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| Institution: | 1. Department of Medicine, Los Angeles, California.;2. Division of Endocrinology, Los Angeles, California.;3. Department of Neurosurgery, Los Angeles, California.;4. Department of Imaging, Los Angeles, California.;5. Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.;1. Departments of Endocrinology, Instituto Português de Oncologia de Lisboa;2. Departments of Nuclear Medicine Department, Instituto Português de Oncologia de Lisboa;3. Departments of University Clinic of Endocrinology, Faculdade de Ciências Médicas, Universidade Nova de Lisboa.;1. Division of Endocrinology and Metabolism, University of California, San Francisco;2. Division of General Internal Medicine, Department of Medicine, University of California, San Francisco.;1. Division of Endocrinology, Diabetes, and Metabolism, Santa Croce and Carle, Cuneo, Italy;2. Department of Radiology, Santa Croce and Carle, Cuneo, Italy,;3. Endocrinology Service, Galeazzi Institute IRCCS, Milan, Italy,;4. Division of Nephrology, Santa Croce and Carle, Cuneo, Italy. |
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| Abstract: | ObjectiveOur objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.MethodsThis is a case report.ResultsDespite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum.ConclusionThis case broadens the clinical spectrum of lymphocytic hypophysitis. (Endocr Pract. 2014;20:e225-e229) |
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