Advanced Bone Age and Hyperinsulinemia in Overweight and Obese Children |
| |
| Affiliation: | 1. Pediatric Endocrinology and Diabetes Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel;2. Sackler School of Medicine, Tel-Aviv University, Israel;3. Women and Children’s Health Research Unit, Gertner Institute.;1. Department of Internal Medicine, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota;2. Department of Endocrinology, Central DuPage Hospital, Winfield, Illinois;3. Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota;4. Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic, Rochester, Minnesota.;1. Department of Otolaryngology, Head, and Neck Surgery;2. Department of Endocrinology;3. Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania.;1. Clinical Department of Neurosurgery, Clinical Hospital Center, Spinciceva 1, 21000, Split, Croatia;2. Department of Neurology, Clinical Hospital Center, Spinciceva 1, 21000, Split, Croatia.;1. Department of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;2. Department of Cardiology, Bergama Government Hospital, Izmir, Turkey;3. Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;4. Department of Endocrinology and Metabolism, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey;5. Department of General Surgery, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;6. Department of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey;7. Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara University, Ankara, Turkey. |
| |
| Abstract: | ObjectiveIn obese children, bone age (BA) tends to significantly exceed chronological age (CA). In vitro studies in mice suggest that insulin may directly modulate skeletal growth. We investigated whether there is an association between fasting insulinand BAmaturationinobesechildren.MethodsThe study cohort comprised 74 overweight and obese children ages 4 to 13 years. BA divided by CA was used as an index for bone advancement. Participants were classified into tertiles based on their BA:CA ratio. Advanced BA maturation was defined as the third tertile, with BA:CA > 1.21. Components of the metabolic syndrome, including fasting insulin, fasting glucose, triglycerides, and high-density lipoprotein (HDL) levels, were measured.ResultsChildren with advanced BA were significantly younger, had a higher body mass index (BMI)-Z score (BMI-Z), and were taller than children with bone advancement in the lower tertiles. Females had a 4.7-fold increased risk for advanced BA compared with males (95% confidence interval [CI], 1.29-17.1; P = .02). Children with a BMI-Z ≥ 1.96 and fasting insulin ≤ 30 μU/L had a 3.6-fold increased risk of advanced BA (95% CI, 1.00-12.8; P = 0.05). Moreover, hyperinsulinemia (fasting insulin > 30 μU/L) was associated with a 6.8-fold increased risk for advanced BA, independent of the degree of obesity (95% CI, 1.45-32.1; P = .01).ConclusionMarked hyperinsulinemia is associated with advanced BA in obese children. Insulin appears to modulate skeletal growth in humans. (Endocr Pract. 2014;20:62-67) |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
