Effect of metabolic inhibitors on growth and brefeldin A formation inCurvularia lunata |
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| Authors: | C T Sam |
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| Institution: | (1) Department of Pharmacy, University of Sydney, 2006 Sydney, New South Wales, Australia;(2) Present address: 2-V, Lorong Delima Sembilan, Island Glades, Penang, Malaysia |
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| Abstract: | Arsenite as opposed to azide exerted a stronger inhibitory effect on brefeldin A production than on mycelial growth of cultures
ofCurvularia lunata. However, azide was a more potent inhibitor of mycelial growth than arsenite at 0.5 mn and 1.0 mm. The inhibitory effects
of iodoacetate on growth and brefeldin A formation were significantly less potent than those of iosoacetamide. Increases in
the levels of fluoride elicited a variable inhibitory effect on brefeldin A production and a corresponding deorease in biomass. |
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