Spring Time and Autumn Time Toxic Effects of Copper (II), 3-(2-Furyl) Prop-2-Enal Semicarbazone and [CuCl2(FASC)2] Complex in Mice |
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| Authors: | B. Jamali G. Ibrahim G. Bouet M.A. Khan P. Allain X. Do Thanh |
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| Affiliation: | Zentrale Tierversuchsanlage , Univ. Ulm (MNH) , Parkstrasse 1, Ulm, 7900, Germany |
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| Abstract: | In vitro, 3-(2-furyl) prop-2-enal semicarbazone-copper (II) complex [CuCl2(FASC)2] presents antimitotic effects. In this work we studied the in vivo seasonal toxic effects in male Swiss mice of CuCl2, and FASC and the [CuCl2(FASC)2] complex. In spring, one injection of CuCl28.10-2 mmol killed 16% of animals after 24 h. Cupric chloride lethal dose was up to 64.10-2 mmol with 100% mice dead after 24 h. FASC was well tolerated from 0.65 to 1.3 mmol. The complex was 100% lethal with 48.10?2 mmol. In autumn, mice were more sensitive to CuCl2 and to the complex with lethal doses up to 32.10-2 mmol and 8.10-2 mmol, respectively. On the other hand, FASC was well tolerated. It is concluded that the in vivo toxic effects of CuCl2 and [CuCl2(FASC)2] complex are quite different in spring and autumn. |
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| Keywords: | Faeces excretion rhythm |
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