Synthesis and hybridization property of novel 2',5'-isoDNA mimic chiral peptide nucleic acids |
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| Authors: | Abdel-Aziz Mohamed Yamasaki Tetsuo Otsuka Masami |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan. |
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| Abstract: | 2',5'-isoDNA mimic chiral peptide nucleic acid (isoPNA) monomers derived from D- and L-aspartic acids were synthesized. These novel monomers were incorporated in aminoethylglycine peptide nucleic acid (aegPNA) thymine dodecamers, and the hybridization properties to RNA and DNA were demonstrated by UV thermal denaturation. |
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