| Executionary pathway for apoptosis：lessons from mutant mice |
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| 引用本文： | Woo M,Hakem R,Mak TW. Executionary pathway for apoptosis：lessons from mutant mice[J]. Cell research, 2000, 10(4): 267-278 |
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| 作者姓名： | Woo M Hakem R Mak TW |
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| 作者单位： | AmgenInstituteandOntarioCancerInstitute,DepartmentsofImmunologyandMedicalBiophysics,UniversityofToron |
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| 摘 要： | Apoptosis or programmed cell death(PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms.Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer.The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the more complex apoptotic pathways that exist in mammals.In this review,we will discuss the apoptotic pathways that are emerging in mammals as elucidated by studies of gene-targeted mutant mice.
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| 关 键 词： | 细胞凋亡 信号通路 突变鼠 线粒体 死亡受体 |
Executionary pathway for apoptosis: lessons from mutant mice |
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| Woo M,Hakem R,Mak T W. Executionary pathway for apoptosis: lessons from mutant mice[J]. Cell research, 2000, 10(4): 267-278 |
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| Authors: | Woo M Hakem R Mak T W |
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| Affiliation: | Amgen Institute and Ontario Cancer Institute, Department of Immunology, University of Toronto, Canada. mwoo@oci.utoronto.ca |
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| Abstract: | Apoptosis or programmed cell death (PCD) is an evolutionarily conserved cellular process that is essential for normal development and homeostasis of multicellular organisms. Defects in the apoptosis signaling result in many diseases including autoimmune diseases and cancer. The apoptosis signaling pathway was first described genetically in the nematode Caenorhabditis elegans which serves as a framework for the more complex apoptotic pathways that exist in mammals. In this review, we will discuss the apoptotic pathways that are emerging in mammals as elucidated by studies of gene-targeted mutant mice. |
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