| The expression of glucose regulated protein—94 in colorectal carcinoma cells treated by sodium butyrate |
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| 引用本文： | Wu YD,Song JD. The expression of glucose regulated protein—94 in colorectal carcinoma cells treated by sodium butyrate[J]. Cell research, 2000, 10(2): 115-125 |
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| 作者姓名： | Wu YD Song JD |
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| 作者单位： | KeyLaboratoryofCellBiology,MinistryofPublicHealthofChinaInstituteofMedicalMolecularBiology,ChinaMedic |
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| 摘 要： | The expression of glucose regulated protein 94 (GPR94) during the treatment of human colorectal carcinoma cell lineClone A cells with codium butyrate was studied.Dodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at G0/G1 stage and cell differentiation as observed by morphological changes,MTT and flow cytometry assays,as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays.The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed.
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| 关 键 词： | 丁酸钠处理 结直肠肿瘤细胞 葡萄糖调控蛋白－94 表达 Grp94 应激蛋白 |
The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate |
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| Wu Y D,Song J D. The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate[J]. Cell research, 2000, 10(2): 115-125 |
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| Authors: | Wu Y D Song J D |
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| Affiliation: | Key Laboratory of Cell Biology, Ministry of Public Health of China. |
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| Abstract: | The expression of glucose regulated protein 94 (GRP94)during the treatment of human colorectal carcinoma cell lineClone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at Go/G1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed. |
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| Keywords: | HSPs Grp94 sodium butyrate colorectal carcinoma cells |
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