Influence of p-dimethylaminoazobenzene and doxorubicin on tobacco cell growth (Nicotiana tabacum L.) |
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| Authors: | Francisco A. Culiáñez-macià Eduardo Primo-Millo José Hernández-Yago José Guerri-Sirera Eduardo Primo-Yúfera |
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| Affiliation: | (1) Catedra de Bioquímica y Química Agrícola de la E.T.S.I.A., Universidad Politécnica, Camino de Vera 14, 46022 Valencia, Spain;(2) Departmento Nacional de Citricultura, C.R.I.D.A. 07, Instituto Nacional de Investigaciones Agrarias, Moncada, (Valencia), Spain;(3) Laboratorio de Microscopía Electrónica, Instituto de Investigaciones Citológicas, Amadeo de Saboya 4, Valencia, Spain |
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| Abstract: | Callus growth, in tobacco pith tissue culture, is activated by p-dimethylaminoazobenzene (p-DAAB), whose carcinogenic properties are well known. Ultrastructural changes, appearing in a period prior to initiation of cell proliferation, occur earlier and more intensely in the presence of the carcinogen. This also influences changes in non-histone chromatin proteins (NHCP). Doxorubicin (DR), an anti-tumor drug, inhibits callus growth and modifies the pattern of NHCP. |
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| Keywords: | Tissue culture cell growth non-histone chromatin proteins Nicotiana p-dimethylaminoazobenzene doxorubicin |
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