A novel and short synthesis of (1,4/2)-cyclohex-5-ene-triol and its conversion to (+/-)-proto-quercitol |
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Authors: | Gültekin M Serdar Salamci Emine Balci Metin |
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Institution: | Department of Chemistry, Faculty of Arts and Sciences, Atatürk University, 25240 Erzurum, Turkey. |
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Abstract: | (1,4/2)-cyclohex-5-ene-triol was synthesized starting from cyclohexa-1,4-diene with two different approaches. Photooxygenation of cyclohexa-1,4-diene and epoxy-cyclohexene afforded anti-2,3-dioxabicyclo2.2.2]oct-7-en-5-yl hydroperoxide and anti-7-oxabicyclo4.1.0]hept-4-en-3-yl hydroperoxide, respectively. Hydroperoxy endoperoxide was reduced with aqueous sodium bisulfite; hydroperoxy-epoxide with dimethylsulfide-titanium tetraisopropoxide to give 7-oxabicyclo4.1.0]hept-4-en-3-ol. Acidic hydrolysis of the epoxy-alcohol gave the (1,4/2)-cyclohex-3-ene-triol. Oxidation of the double bond with KMnO4 resulted in the formation of (+/-)-proto-quercitol. |
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Keywords: | Quercitol Singlet oxygen Ene-reaction Endoperoxide Hydroperoxide |
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