Owl monkey gene map: evidence for a homologous human chromosome 7q region near the cystic fibrosis locus |
| |
| Authors: | N S Ma T S Harris P Watkins L C Tsui |
| |
| Institution: | New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772. |
| |
| Abstract: | We have demonstrated the assignments of two gene loci (COLIA2, MET) and two noncoding DNA markers (D7S13, D7S8) to owl monkey chromosome 14 (K-VI) by hybridizing DNA probes from the cystic fibrosis (CF) region of human chromosome 7q21-32 to panels of rodent-owl monkey somatic cell hybrids. The assignments are substantiated by in situ chromosome hybridization of markers COLIA2, MET, and D7S13 to the distal long arm of chromosome 14 (K-VI). These results support genomic conservation of the human CF region, at least in the higher primates. |
| |
| Keywords: | |
|
|
