Study of different copper (I) catalysts for the "click chemistry" approach to carbanucleosides |
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| Authors: | Broggi Julie Joubert Nicolas Aucagne Vincent Zevaco Thomas Berteina-Raboin Sabine Nolan Steve P Agrofoglio Luigi A |
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| Institution: | Institut de Chimie Organique et Analytique, Université d'Orléans, Orléans, France. |
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| Abstract: | We compare herein the scope of three copper (I) catalysts on the synthesis of various 1,4-disubstitued-1,2,3-triazolo-carbanucleosides through a microwave (and thermic) assisted Huisgen 1,3-dipolar cycloaddition. The tetrakis(acetonitrile)copper hexafluorophosphate (Cu(CH3CN)4]PF6), the imidazoline(mesythyl)copper bromide (Imes)CuBr, and the copper/copper sulfate Cu(0)/CuSO4 (II) mixture have been chosen for this study. Their influence in a catalytic amount will be analyzed according to the substituent of the alkyne, the solvent, or the heating method. |
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