Relationship Between IL-2, IL-17 Concentrations,and Serum Creatinine Levels in Men with Chronic Kidney Diseases |
| |
| Authors: | Khalid Farouq Al-rawi Hameed Hussein Ali Manaf Abdulrahman Guma Bilal Jasir Mohammed Aldahham Shakir Faris Tuleab Alaaraji Osamah Al-ani Aus Tariq Ali |
| |
| Affiliation: | 1. Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. ; 2. Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. ; 3. Department of Chemistry, College of Education for pure Science, University of Anbar, Al-anbar Province, Iraq. ; 4. Yarmouk Academic Hospital, Baghdad, Iraq. ; 5. University of Anbar, Al-anbar Province, Iraq. |
| |
| Abstract: | Background:Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more prevalent in developed countries compared with the rest of the world, due to the higher rates of life expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD.Methods:Forty-five men with CKD and seventy controls were enrolled in the current study to assess the relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17 were measured in patients with CKD and their controls, and then the relationship between these interleukins and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated.Results:A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively.Conclusion:IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts are needed to confirm these observations.Key Words: Chronic kidney disease, Interleukins, Serum creatinine, Serum urea, Urine albumin |
| |
| Keywords: | |
|
|
