Electrochemical aptamer-based sensors |
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Authors: | Beatriz Prieto-Simón Mònica Campàs Jean-Louis Marty |
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Affiliation: | 1. Institut de Bioenginyeria de Catalunya (IBEC), C/Baldiri Reixac 10-12, 08028, Barcelona, Spain 2. IRTA, Ctra. Poble Nou, km. 5.5, 43540, Sant Carles de la Ràpita, Spain 3. Université de Perpignan Via Domitia, IMAGES EA4218, Building S 52 Av. Paul Alduy, 66860, Perpignan Cedex, France
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Abstract: | The valuable properties of aptamers, such as specificity, sensitivity, stability, cost-effectiveness and design flexibility, have favoured their use as biorecognition elements in biosensor development. These synthetic affinity probes can be developed for almost any target molecule, covering a wide range of applications in fields such as clinical diagnosis and therapy, environmental monitoring and food control. The combination of aptamers with high-performance electrochemical transducers, with their inherent high sensitivities, fast response times and simple equipment, has already provided several electrochemical aptamer-based sensors. Moreover, the small size and versatility of aptamers allow efficient immobilisations in high-density monolayers, an important feature towards miniaturisation and integration of compact electrochemical devices. This review describes the state-of-the-art of electrochemical aptamer-based sensors, entering into the details of the different strategies and types of electrochemical transduction and also considering their advantages when applied to the analysis of complex matrices. |
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