Chronic neurobehavioral and central and autonomic nervous system effects of Tokyo subway sarin poisoning |
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| Affiliation: | 1. Department of Public Health and Occupational Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan;2. Emergency Department, St. Luke''s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-0044, Japan;1. Process Technology Development Division, Defence Research & Development Establishment, Jhansi road, Gwalior 474 002, India;2. School of Studies in Chemistry, Jiwaji University, Gwalior, India;1. Yokohama City University, Mass Spectrometry Laboratory, 22-2 Seto, Kanazawa-ku, Yokohama, Japan;2. Nihon Waters, Technology Application Department, Nihon Waters K.K., 1-3-12 Kitashinagawa, Shinagawa, Tokyo, Japan;3. Shiseido, Analytical Research Group, 2-2-1 Hayabuchi, Tuszuki-ku, Yokohama, Japan;1. Estación Experimental INTA Famaillá, Ruta Provincial 301, km 32, 4132 Famaillá, Tucumán, Argentina;2. CONICET, Buenos Aires, Argentina;3. Estación Experimental INTA Salta, Ruta Nacional 68, km 172, 4403 Salta, Argentina |
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| Abstract: | To evaluate delayed (prolonged) neurobehavioral and neurophysiological effects of acute sarin poisoning, nine male and nine female patients of the Tokyo subway sarin poisoning in Japan were examined by neurobehavioral tests, posttraumatic stress disorder (PTSD) checklist, brain evoked potentials, computerized static posturography, and electrocardiographic R-R interval variability, 6–8 months after the poisoning. Their serum cholinesterase activities on the day of the poisoning (March 20, 1995) were 13–131 (mean 72.1) IU/L. The results suggested delayed effects on psychomotor performance, the higher and visual nervous system and the vestibulo-cerebellar system with psychiatric symptoms resulting from PTSD. |
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